Description

2-[3-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane is a versatile and high-value organoboron building block, specifically a bromomethyl-substituted phenyl dioxaborinane. This compound is critical for its dual functionality, offering both a reactive benzyl bromide handle and a protected boronic acid moiety, enabling precise synthetic transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key electrophilic or protected nucleophilic partner for constructing biaryl and heterobiaryl structures central to many drug candidates.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel therapeutic agents, including kinase inhibitors, antiviral compounds, and CNS-active molecules.
• Agrochemical Active Ingredient Development: Employed in creating advanced intermediates for new herbicides, fungicides, and insecticides.
• Material Science and OLED Research: Acts as a precursor for synthesizing organic semiconductors, ligands for catalysts, and fluorescent materials.
• Peptide and Protein Modification: The reactive bromomethyl group allows for selective alkylation or conjugation in bioconjugation chemistry.
• Library Synthesis for Drug Discovery: A valuable building block in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2-[3-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane
CAS No.	223799-25-5
Molecular Formula	C13H18BBrO2
Molecular Weight	297.00 g/mol
Synonyms	3-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzyl Bromide; (3-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-(3-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3-Bromomethylphenylboronic Acid 1,3-Propanediol Cyclic Ester; m-(Bromomethyl)phenylboronic Acid Neopentyl Glycol Ester; (3-(Bromomethyl)phenyl)boronic Acid, Cyclic Ester with 2,2-Dimethyl-1,3-propanediol
EINECS	Contact for details

Quality Control

Every batch of 2-[3-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.