Description

2-Bromo-2'-Fluoro-6'-(Trifluoromethyl)Acetophenone, also known as 2-Bromo-1-[2-Fluoro-6-(Trifluoromethyl)Phenyl]Ethan-1-One, is a high-value fluorinated and brominated aromatic ketone building block. This compound matters for its unique molecular architecture, which combines halogen atoms at strategic positions to enable sophisticated chemical transformations in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic core and halogen functionalities.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form biaryl structures.
• Fluorine Chemistry Building Block: Essential for introducing the 2-fluoro-6-(trifluoromethyl)phenyl moiety into more complex molecular systems.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library development in drug discovery programs.

Basic Information

Product Name	2-Bromo-2'-Fluoro-6'-(Trifluoromethyl)Acetophenone
CAS No.	223785-85-1
Molecular Formula	C9H5BrF4O
Molecular Weight	285.04 g/mol
Synonyms	2-Bromo-1-[2-fluoro-6-(trifluoromethyl)phenyl]ethan-1-one; 2-Bromo-1-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone; 2'-Fluoro-2-bromo-6'-(trifluoromethyl)acetophenone; α-Bromo-2-fluoro-6-(trifluoromethyl)acetophenone; 1-(2-Fluoro-6-(trifluoromethyl)phenyl)-2-bromoethanone; 2-Bromo-2-fluoro-6-trifluoromethyl acetophenone; Ethanone, 2-bromo-1-[2-fluoro-6-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-Bromo-2'-Fluoro-6'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and protect from physical damage. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.