Description

2,3-Dihydro-(1R)-Methyl-5-(Tetrahydro-4H-1,3,6,2-Dioxazaborocin-2-Yl)-2-(Triphenylmethyl)-1H-Isoindole is a sophisticated chiral building block and advanced intermediate, primarily valued for its role in the synthesis of complex pharmaceutical molecules. Its unique structure, featuring a fused isoindole ring and a trityl-protected nitrogen, makes it a critical component in constructing active pharmaceutical ingredients (APIs) with high stereochemical purity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly for projects involving boron-containing therapeutics and novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates, especially those targeting neurological and oncological pathways.
• Boron Neutron Capture Therapy (BNCT) Agent Precursor: Serves as a sophisticated precursor for developing boron-containing compounds used in experimental cancer treatment technologies.
• Asymmetric Catalysis & Ligand Synthesis: Utilized in the development of novel chiral ligands and catalysts for asymmetric synthesis, leveraging its rigid, three-dimensional structure.
• Process Chemistry & Scale-Up: Employed in kilogram-scale GMP manufacturing for clinical trial material and commercial API production, where consistent high purity is paramount.
• Academic & Contract Research: Used in university and CRO settings for methodological development and exploring new chemical spaces in medicinal chemistry.
• Protease Inhibitor Development: Acts as a core structural motif in the design and synthesis of protease enzyme inhibitors.

Basic Information

Product Name	2,3-Dihydro-(1R)-Methyl-5-(Tetrahydro-4H-1,3,6,2-Dioxazaborocin-2-Yl)-2-(Triphenylmethyl)-1H-Isoindole
CAS No.	223595-20-8
Molecular Formula	C33H32BNO2
Molecular Weight	485.43 g/mol
Synonyms	(1R)-2,3-Dihydro-1-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-(triphenylmethyl)-1H-isoindole; 1H-Isoindole, 2,3-dihydro-1-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-(triphenylmethyl)-, (1R)-; (R)-2,3-Dihydro-1-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-trityl-1H-isoindole; Trityl-protected Boron-Isoindole Intermediate; CAS 223595-20-8
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment, and consideration should be given to handling under an inert atmosphere for long-term storage or after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.