Description

2-Bromo-5,6-Difluoro-2,3-Dihydro-1H-Inden-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated indanone structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas where fluorinated and brominated scaffolds are essential for modulating bioactivity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel fluorinated pesticides and herbicides, leveraging the biological activity imparted by the difluoro and bromo substituents.
• Material Science Precursor: Serves as a starting material for the development of specialty chemicals and advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for methodological studies in organic synthesis and halogenation chemistry.
• Fluorine Chemistry Building Block: Essential for exploring structure-activity relationships (SAR) in medicinal chemistry due to its specific fluorine substitution pattern.

Basic Information

Product Name	2-Bromo-5,6-Difluoro-2,3-Dihydro-1H-Inden-1-One
CAS No.	222992-13-4
Molecular Formula	C9H5BrF2O
Molecular Weight	247.04 g/mol
Synonyms	2-Bromo-5,6-difluoroindan-1-one; 5,6-Difluoro-2-bromo-1-indanone; 1H-Inden-1-one, 2-bromo-5,6-difluoro-2,3-dihydro-; 2-Bromo-5,6-difluoro-2,3-dihydroinden-1-one; 222992-13-4; 2-Bromo-5,6-difluoroindanone
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5,6-Difluoro-2,3-Dihydro-1H-Inden-1-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.