Description

5-Isoxazolecarboxaldehyde, 3-Chloro- (9Ci) is a versatile heterocyclic aldehyde building block used in advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the aldehyde group and the halogenated isoxazole ring enable the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals. Its specific structure makes it a key intermediate for synthesizing compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole moiety.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed reactions and organocatalysts due to its chelating potential.
• Material Science Research: Acts as a building block for creating functional polymers and organic electronic materials with specific optoelectronic properties.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and enzyme mechanisms.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including cycloaddition and cross-coupling reactions.

Basic Information

Product Name	5-Isoxazolecarboxaldehyde, 3-Chloro- (9Ci)
CAS No.	220780-53-0
Molecular Formula	C4H2ClNO2
Molecular Weight	131.52 g/mol
Synonyms	3-Chloro-5-formylisoxazole; 3-Chloroisoxazole-5-carboxaldehyde; 3-Chloro-1,2-oxazole-5-carbaldehyde; 5-Formyl-3-chloroisoxazole; 3-Chloro-5-isoxazolecarboxaldehyde; 3-Chloro-5-isoxazolecarbaldehyde; 3-Chloro-1,2-oxazole-5-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 5-Isoxazolecarboxaldehyde, 3-Chloro- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to strict in-house quality standards suitable for research and industrial-scale synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay (purity) and impurity profiles determined by HPLC, GC, and NMR. Our quality management system supports traceability and batch-to-batch reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.