Description

2-Azabicyclo[2.1.1]Hexane-2,4-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester is a high-value, synthetically challenging bicyclic building block used in advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to explore novel three-dimensional chemical space and modulate the physicochemical properties of drug candidates. It is primarily utilized by R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of complex molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry: Used to introduce conformational constraint and improve metabolic stability, potency, and selectivity in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Acts as a specialized linker or component in the design of bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the construction of tool compounds for target validation and pathway elucidation studies.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective catalytic processes to create enantiomerically pure compounds.
• Agrochemical Research: Potential application in the development of novel, high-performance crop protection agents with unique modes of action.

Basic Information

Product Name	2-Azabicyclo[2.1.1]Hexane-2,4-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester
CAS No.	220598-45-8
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	tert-Butyl 2-azabicyclo[2.1.1]hexane-2,4-dicarboxylate; 2-(tert-Butoxycarbonyl)-2-azabicyclo[2.1.1]hexane-4-carboxylic acid; 2-Azabicyclo[2.1.1]hexane-2,4-dicarboxylic acid, 2-tert-butyl ester; Bicyclo[2.1.1]hexane-2,4-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, 2-aza-; 2-Boc-2-azabicyclo[2.1.1]hexane-4-carboxylic acid; 220598-45-8; 2-Aza-bicyclo[2.1.1]hexane-2,4-dicarboxylic acid 2-tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Azabicyclo[2.1.1]Hexane-2,4-Dicarboxylic Acid, 2-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.