Description

(S)-Methyl 2-(tert-Butoxycarbonylamino)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate is a high-purity, chiral boronic ester derivative designed for advanced pharmaceutical and chemical synthesis. This compound matters as a critical, protected building block for the efficient construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research scientists and process chemists in pharmaceutical R&D, agrochemical development, and specialty chemical manufacturing for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for the formation of carbon-carbon bonds with aryl/heteroaryl halides.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and constrained amino acid derivatives for medicinal chemistry.
• Agrochemical Synthesis: Employed as a building block for developing novel herbicides, fungicides, and insecticides with chiral centers.
• Material Science: Facilitates the creation of functionalized polymers and organic electronic materials through controlled coupling reactions.
• Chemical Biology Probes: Utilized in the preparation of labeled compounds and molecular probes for target identification and binding studies.

Basic Information

Item	Detail
Product Name	(S)-Methyl 2-(tert-Butoxycarbonylamino)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate
CAS No.	220587-29-1
Molecular Formula	C21H32BNO6
Molecular Weight	405.30 g/mol
Synonyms	Boc-L-4-Boronophenylalanine Methyl Ester Pinacol Ester; (S)-Methyl 2-((tert-Butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; Boc-Phe(4-Bpin)-OMe; L-4-Pinacolatoboronophenylalanine N-Boc Methyl Ester; Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate; Boc-Phe(4-BPin)-O-Me; (S)-Boc-4-Bpin-Phe-OMe
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-(tert-Butoxycarbonylamino)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and LC-MS, to ensure high chemical and enantiomeric purity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with full characterization data are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, freezer environment. This product is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.