Description

(R)-2-Isopropyl-Succinic Acid-1-Methyl Ester is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its defined stereochemistry makes it a valuable building block for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiopure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and development of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic and R&D: A critical reagent in university and corporate research laboratories for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(R)-2-Isopropyl-Succinic Acid-1-Methyl Ester
CAS No.	220498-08-8
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(R)-1-Methyl 2-isopropylsuccinate; (R)-Methyl 2-isopropylbutanedioate; (2R)-2-(1-Methylethyl)butanedioic acid 1-methyl ester; (R)-2-Isopropylsuccinic acid monomethyl ester; (R)-Methyl hydrogen 2-isopropylsuccinate; (R)-2-(Propan-2-yl)succinic acid methyl ester; (R)-Mono-methyl 2-isopropylsuccinate
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Production adheres to current Good Manufacturing Practice (cGMP) principles where applicable, ensuring batch-to-batch consistency and high enantiomeric excess (ee). Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.