Description

2',4',5'-Trifluoropropiophenone is a high-value fluorinated aromatic ketone building block, recognized for its role as a key intermediate in advanced organic synthesis. Its precise trifluorinated pattern offers unique electronic and steric properties, enabling the construction of complex molecules with tailored functionality. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing a trifluoromethylphenyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals, which are vital components in high-performance display technologies.
• Organic Electronics: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors due to its electron-withdrawing characteristics.
• Chemical Research: A versatile reagent for method development in cross-coupling reactions, carbonyl chemistry, and fluorine chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2',4',5'-Trifluoropropiophenone
CAS No.	220228-07-9
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	1-(2,4,5-Trifluorophenyl)propan-1-one; 2,4,5-Trifluoropropiophenone; Propiophenone, 2',4',5'-trifluoro-; 2,4,5-Trifluoro-1-propiophenone; α-Ethyl-2,4,5-trifluoroacetophenone; 2,4,5-Trifluoroethyl phenyl ketone
EINECS	Contact for details

Quality Control

Our 2',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.