Description

4-Hydroxy-3-(Trifluoromethyl)Benzaldehyde is a versatile trifluoromethylated aromatic aldehyde that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with a reactive aldehyde and a trifluoromethyl substituent, makes it a high-value intermediate for creating complex molecules with enhanced properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the introduction of the CF3 group can enhance pesticidal activity and environmental profile.
• Liquid Crystal Materials: Serves as a core building block for fluorine-containing liquid crystal molecules used in advanced display technologies (LCDs).
• Specialty Polymer Monomer: Incorporated into polymer backbones to create materials with specific optical, thermal, or surface properties for high-performance coatings and engineering plastics.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, condensations, and as a scaffold for constructing complex heterocycles in medicinal and materials chemistry research.
• Chemical Research & Development: Utilized as a standard or starting material in academic and industrial R&D labs for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	4-Hydroxy-3-(Trifluoromethyl)Benzaldehyde
CAS No.	220227-98-5
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	3-(Trifluoromethyl)-4-hydroxybenzaldehyde; 4-Hydroxy-3-trifluoromethylbenzaldehyde; 4-Hydroxy-α,α,α-trifluoro-m-tolualdehyde; 2-Trifluoromethyl-4-formylphenol; 4-Formyl-2-(trifluoromethyl)phenol; m-Trifluoromethyl-p-hydroxybenzaldehyde; 4-Hydroxy-3-(trifluoromethyl)benzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-3-(Trifluoromethyl)Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.