Description

2'-(Trifluoromethoxy)Acetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethoxy substituent, which is a key pharmacophore in modern drug design. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for novel fluorinated liquid crystals, polymers, and organic electronic materials that require specific dielectric and optical properties.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying enzyme mechanisms and protein interactions due to its distinct spectroscopic signature.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2'-(Trifluoromethoxy)Acetophenone
CAS No.	220227-93-0
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-[2-(Trifluoromethoxy)phenyl]ethanone; 2-Acetylphenyl trifluoromethyl ether; 2'-Trifluoromethoxyacetophenone; 2-(Trifluoromethoxy)acetophenone; α,α,α-Trifluoro-o-methoxyacetophenone; o-(Trifluoromethoxy)acetophenone; 2-Trifluoromethoxyacetophenone; 2-Acetylphenyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our 2'-(Trifluoromethoxy)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.