Description

3',4',5'-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone building block, identified by CAS NO 220227-74-7. This compound is valued for its unique trifluoromethyl-substituted phenyl ring, which imparts enhanced metabolic stability and lipophilicity to target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates in active ingredient development.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug candidates.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display applications.
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport materials and host materials for OLED devices.
• Advanced Material Research: Utilized in academic and industrial R&D for creating novel polymers and specialty chemicals with tailored properties.
• Fluorine Chemistry Building Block: A versatile starting material for further functionalization via reactions such as nucleophilic substitution or reduction to corresponding alcohols.

Basic Information

Product Name	3',4',5'-Trifluoropropiophenone
CAS No.	220227-74-7
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)propan-1-one; 3,4,5-Trifluoropropiophenone; 3,4,5-Trifluorophenyl Ethyl Ketone; 3,4,5-Trifluoro Propiophenone; 3,4,5-Trifluoro-1-propiophenone; 3,4,5-Trifluorobenzoylethane; 3,4,5-Trifluoro-ω-ethylacetophenone; 220227-74-7
EINECS	Contact for details

Quality Control

Our 3',4',5'-Trifluoropropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.