Description

4'-Hydroxy-2'-Trifluoromethylacetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and a trifluoromethyl group, makes it a versatile intermediate for creating complex molecules with enhanced properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Chemistry: Employed in the development of specialty polymers and coatings with specific thermal, chemical, or surface properties.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination chemistry and cross-coupling reactions in academic and industrial labs.

Basic Information

Product Name	4'-Hydroxy-2'-Trifluoromethylacetophenone
CAS No.	220227-53-2
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-(4-Hydroxy-2-(trifluoromethyl)phenyl)ethan-1-one; 2'-Trifluoromethyl-4'-hydroxyacetophenone; 4-Hydroxy-2-trifluoromethylacetophenone; 1-[4-Hydroxy-2-(trifluoromethyl)phenyl]ethanone; 4'-Hydroxy-α,α,α-trifluoro-o-acetophenone; HTA; CF3-acetophenone derivative
EINECS	Contact for details

Quality Control

Our 4'-Hydroxy-2'-Trifluoromethylacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.