Description

Ethanone, 2-Bromo-1-(2-Fluoro-4-Hydroxyphenyl)- is a specialized halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromo, fluoro, and phenolic hydroxyl groups, makes it a versatile intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by pharmaceutical and agrochemical research & development teams for creating novel active ingredients and fine-tuning material properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides, where the fluorine and bromine atoms can enhance efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify molecular polarity and intermolecular interactions.
• Chemical Biology & Proteomics: Employed as a reactive handle or linker in the design of chemical probes, photoaffinity labels, or PROTACs for target identification and degradation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific halogenated scaffold.

Basic Information

Product Name	Ethanone, 2-Bromo-1-(2-Fluoro-4-Hydroxyphenyl)-
CAS No.	220131-30-6
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	2-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone; 2'-Fluoro-4'-hydroxy-2-bromoacetophenone; 2-Bromo-2'-fluoro-4'-hydroxyacetophenone; 1-(2-Fluoro-4-hydroxyphenyl)-2-bromoethanone; α-Bromo-2'-fluoro-4'-hydroxyacetophenone; 2-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethan-1-one; (2-Fluoro-4-hydroxyphenyl) bromomethyl ketone
EINECS	Contact for details

Quality Control

Our production of Ethanone, 2-Bromo-1-(2-Fluoro-4-Hydroxyphenyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed due to the compound's light-sensitive nature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.