Description

7-Trifluoromethyl-2,3,4,5-Tetrahydro-1H-Benzo[B]Azepine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzo-fused azepine ring system. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and other therapeutic agents, where its structural motif is a key pharmacophore.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Organic Synthesis Building Block: Used in medicinal chemistry for the construction of complex heterocyclic molecules due to its benzoazepine core and trifluoromethyl group.
• Chemical Research & Development: Serves as a standard or reference compound in analytical method development and structure-activity relationship (SAR) studies.
• Preclinical & Clinical Trial Material: Supplied in high-purity grades for use in the synthesis of compounds intended for non-clinical and clinical studies.

Basic Information

Product Name	7-Trifluoromethyl-2,3,4,5-Tetrahydro-1H-Benzo[B]Azepine Hydrochloride
CAS No.	220107-24-4
Molecular Formula	C11H13ClF3N
Molecular Weight	251.68 g/mol
Synonyms	1H-2-Benzazepine, 2,3,4,5-tetrahydro-7-(trifluoromethyl)-, hydrochloride; 7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride; 7-Trifluoromethyl-1,2,3,5-tetrahydro-4H-2-benzazepine hydrochloride; 7-Trifluoromethyl-2,3,4,5-tetrahydro-1H-2-benzazepine HCl; 7-Trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine hydrochloride
EINECS	Contact for details

Quality Control

Our 7-Trifluoromethyl-2,3,4,5-Tetrahydro-1H-Benzo[B]Azepine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.