Description

Isoescin Ib CAS NO 219944-46-4 is a high-purity, standardized triterpenoid saponin compound, a key active constituent derived from Horse Chestnut (*Aesculus hippocastanum* L.). This compound is valued for its precise chemical definition and consistent biological activity, making it a critical reference standard and active ingredient. It is primarily sought by research institutions and manufacturers in the pharmaceutical and nutraceutical sectors. Its well-characterized profile supports advanced development in vascular health and anti-inflammatory applications.

Application

• Pharmaceutical Reference Standard: Used as a primary chemical reference material (CRM) for the quality control and standardization of Horse Chestnut extracts and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the research and development of prescription and OTC medications targeting chronic venous insufficiency (CVI) and related vascular disorders.
• Nutraceutical & Dietary Supplement Formulation: Incorporated into high-end supplement products aimed at supporting circulatory health, reducing edema, and strengthening capillary walls.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate mechanisms of action related to anti-inflammatory, anti-edematous, and venotonic properties.
• Cosmeceutical Applications: Used in topical formulations designed to reduce under-eye puffiness, dark circles, and improve skin microcirculation.
• Analytical Method Development: Essential for developing and validating precise analytical methods, such as HPLC and LC-MS, for the quantification of escin components in complex matrices.

Basic Information

Product Name	Isoescin Ib
CAS No.	219944-46-4
Molecular Formula	C55H86O24
Molecular Weight	1131.26 g/mol
Synonyms	Isoescin Ib; Escin Ib; Aescin Ib; β-Escin; Escin IIb; (3β,16α,21β,22α)-21,22-Diacetoxy-16,28-dihydroxyolean-12-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→2)]-β-D-glucopyranosiduronic acid; Horse Chestnut Saponin Ib
EINECS	Contact for details

Quality Control

Every batch of Isoescin Ib is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets specifications suitable for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters including assay purity by HPLC, related substance profiles, and residual solvent analysis. Specifications can be developed to align with USP/EP monograph requirements for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥95.0%
Loss on Drying	≤5.0%
Residue on Ignition	≤1.0%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤5.0% Any single unknown impurity ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.