Description

14-Deoxy-12-Hydroxyandrographolide is a key diterpenoid lactone derivative, structurally related to andrographolide, a primary bioactive constituent of the medicinal plant Andrographis paniculata. This compound is valued for its role as a critical intermediate and reference standard in pharmaceutical research and development, offering a pathway to novel therapeutic agents. It is primarily sought by research institutions and manufacturers in the pharmaceutical, nutraceutical, and phytochemical industries for applications in anti-inflammatory, antiviral, and immunomodulatory studies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel andrographolide analogs with targeted biological activities.
• Reference Standard: Used as a high-purity analytical standard in HPLC and LC-MS for quality control of herbal extracts and finished products.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate structure-activity relationships (SAR) of diterpenoid compounds.
• Natural Product Chemistry: A key compound for academic and industrial research focused on the isolation, characterization, and modification of plant-derived bioactive molecules.
• Nutraceutical Development: Used in the development of standardized herbal supplements where specific andrographolide derivatives are targeted for enhanced efficacy.

Basic Information

Product Name	14-Deoxy-12-Hydroxyandrographolide
CAS No.	219721-33-2
Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.45 g/mol
Synonyms	14-Deoxy-12-hydroxyandrographolide; 12-Hydroxy-14-deoxyandrographolide; 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; Andrographolide, 14-deoxy-12-hydroxy-; Neoandrographolide related compound
EINECS	Contact for details

Quality Control

Our 14-Deoxy-12-Hydroxyandrographolide is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, related substances, and residual solvents. Our quality systems are designed to support research and development requiring high-purity phytochemical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.