Description

2-(2,2,2-Trifluoroethoxy)Propanoic Acid is a specialized fluorinated organic acid building block, valued for its unique trifluoroethoxy side chain which imparts significant lipophilicity and metabolic stability to target molecules. This compound is critical for the synthesis of advanced agrochemicals and pharmaceuticals, where its structural motif is used to fine-tune biological activity and environmental persistence. It serves as a key intermediate for researchers and manufacturers in the life sciences and specialty chemical sectors seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of new drugs where fluorine substitution is desired for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoroethoxy group can improve pesticidal activity and rainfastness.
• Liquid Crystal Materials: Serves as a precursor or dopant in the synthesis of fluorinated liquid crystals for high-performance displays.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the 2-(2,2,2-trifluoroethoxy)propionyl moiety into more complex molecular architectures in research and development.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Propanoic Acid
CAS No.	217806-37-6
Molecular Formula	C5H7F3O3
Molecular Weight	172.10 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)propionic Acid; α-(2,2,2-Trifluoroethoxy)propionic Acid; Propanoic Acid, 2-(2,2,2-trifluoroethoxy)-; 2-(Trifluoroethoxy)propanoic Acid; TFEPA; 2-TFEPA
EINECS	Contact for details

Quality Control

Our production of 2-(2,2,2-Trifluoroethoxy)Propanoic Acid adheres to stringent in-process controls and final batch testing to ensure consistent purity and performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to support applications requiring high-purity intermediates under GMP or ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, ensure containers are made of compatible materials such as glass or fluorinated polymers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.