Description

Piperazine, 1-[(Trifluoromethyl)Sulfonyl]-, Hydrochloride (1:1) is a specialized, high-purity trifluoromethanesulfonyl (triflyl) derivative of piperazine, designed for advanced synthetic applications. This compound is valued for its role as a key building block and reagent in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the versatile triflyl group into target structures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring sulfonamide or trifluoromethylsulfonyl functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the triflyl group can enhance biological activity.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Piperazine, 1-[(Trifluoromethyl)Sulfonyl]-, Hydrochloride (1:1)
CAS No.	215453-48-8
Molecular Formula	C5H10F3N2O2S • HCl
Molecular Weight	270.66 g/mol
Synonyms	1-(Trifluoromethanesulfonyl)piperazine hydrochloride; N-(Trifluoromethylsulfonyl)piperazine hydrochloride; Piperazine, 1-(trifluoromethylsulfonyl)-, monohydrochloride; 1-(Triflyl)piperazine HCl; Trifluoromethanesulfonamide, N,N-pentamethylene-, hydrochloride; Piperazine triflamide hydrochloride
EINECS	Contact for details

Quality Control

Our Piperazine, 1-[(Trifluoromethyl)Sulfonyl]-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.