Description

5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Indan-1-One is a high-purity organoboron building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester precursor for constructing biaryl and heterobiaryl systems prevalent in pharmaceutical candidates.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules, particularly those containing the indanone scaffold, for therapeutic areas like oncology and CNS disorders.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as OLEDs and semiconductors.
• Agrochemical Synthesis: Employed in the development of new herbicides and fungicides with enhanced efficacy.
• Chemical Biology & Probe Development: Utilized to create tagged molecules and activity-based probes for studying biological pathways.
• Academic & Process R&D: A valuable reagent for methodological development and scaling novel synthetic routes in laboratory and pilot plant settings.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Indan-1-One
CAS No.	214360-81-3
Molecular Formula	C15H19BO3
Molecular Weight	258.12 g/mol
Synonyms	1-Indanone, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-indanone; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)indan-1-one; 5-Indan-1-one boronic acid pinacol ester; 5-Pinacolatoboryl-1-indanone; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our 5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Indan-1-One undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere if possible to maximize long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.