Description

2,4,6-Trimethylbenzeneboronic Acid Neopentyl Glycol Cyclic Ester is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form. This compound is a critical building block in modern synthetic chemistry, particularly valued for its role in cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, essential for synthesizing biaryl structures.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing sterically hindered aromatic systems.
• Agrochemical Synthesis: Serves as a precursor in creating novel herbicides, fungicides, and insecticides with tailored properties.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal catalysis and organometallic complexes.
• Material Science & OLEDs: A building block for creating organic semiconductors, charge-transport materials, and emissive layers in electronic devices.
• Chemical Research & Process Development: Enables scalable, efficient synthetic routes in academic and industrial laboratory settings.

Basic Information

Product Name	2,4,6-Trimethylbenzeneboronic Acid Neopentyl Glycol Cyclic Ester
CAS No.	214360-78-8
Molecular Formula	C14H21BO2
Molecular Weight	232.13 g/mol
Synonyms	2,4,6-Trimethylphenylboronic Acid Neopentyl Glycol Ester; 2,4,6-Trimethylbenzeneboronic Acid Pinanediol Ester (common alternative); Mesitylboronic Acid Neopentyl Glycol Ester; (2,4,6-Trimethylphenyl)boronic Acid Pinacol Ester; 4,4,5,5-Tetramethyl-2-(2,4,6-trimethylphenyl)-1,3,2-dioxaborolane; B-Mesityl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(2,4,6-Trimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,4,6-Trimethylbenzeneboronic Acid Neopentyl Glycol Cyclic Ester is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing including HPLC, NMR, and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP requirements for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.