Description

4,4,5,5-Tetramethyl-2-(3,4,5-Trimethoxyphenyl)-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the efficient synthesis of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly those containing complex, multi-substituted aromatic and heteroaromatic scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific biaryl motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs and OFETs, where precise molecular architecture is crucial.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Academic & Industrial R&D: A fundamental reagent for methodological development and exploring new chemical spaces in cross-coupling chemistry.

Basic Information

Item	Details
Product Name	4,4,5,5-Tetramethyl-2-(3,4,5-Trimethoxyphenyl)-1,3,2-Dioxaborolane
CAS No.	214360-67-5
Molecular Formula	C15H23BO5
Molecular Weight	294.15 g/mol
Synonyms	2-(3,4,5-Trimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,4,5-Trimethoxyphenylboronic Acid Pinacol Ester; (3,4,5-Trimethoxyphenyl)boronic Acid Pinacol Ester; 3,4,5-Trimethoxyphenyl-Bpin; TMOPB Pinacol Ester; Pinacol (3,4,5-Trimethoxyphenyl)boronate; CAS 214360-67-5
EINECS	Contact for details

Quality Control

Every batch of our 4,4,5,5-Tetramethyl-2-(3,4,5-Trimethoxyphenyl)-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive cross-coupling applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supported by techniques such as NMR, HPLC, and GC. Our quality management system is designed to ensure batch-to-batch consistency and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.