Description

4-Trifluoromethylphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. This compound offers superior stability and handling characteristics compared to its free boronic acid counterpart, making it a valuable building block for research and development. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials scientists for constructing complex molecular architectures containing the versatile trifluoromethyl group.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, crucial for drug discovery and material science.
• Pharmaceutical Intermediates: Serves as a critical precursor in the development of active pharmaceutical ingredients (APIs) containing the trifluoromethyl moiety, which enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the CF3 group can improve efficacy and environmental profile.
• Liquid Crystal and OLED Material Development: Employed in the synthesis of advanced organic electronic materials for displays and lighting.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with tailored properties.
• Chemical Biology & Proteomics: Useful as a probe or linker in bioconjugation strategies and the development of enzyme inhibitors.

Basic Information

Product Name	4-Trifluoromethylphenylboronic Acid, Pinacol Ester
CAS No.	214360-65-3
Molecular Formula	C13H16BF3O2
Molecular Weight	272.07 g/mol
Synonyms	4-(Trifluoromethyl)benzeneboronic Acid Pinacol Ester; 2-[4-(Trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Trifluoromethyl)phenylboronic Acid Pinacol Ester; 4-CF3-Phenylboronic Acid Pinacol Ester; (4-Trifluoromethylphenyl)boronic Acid Pinacol Ester; 1,3,2-Dioxaborolane, 2-[4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-; Pinacol 4-(Trifluoromethyl)phenylboronate
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B, 19F), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.