Description

4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in its role as a key boronic ester derivative, enabling critical carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality precursors for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for small molecule drugs targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable, air-tolerant boronic ester partner for palladium-catalyzed coupling reactions to form biaryl structures, a common motif in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Materials Science Research: A precursor for constructing organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological systems.

Basic Information

Item	Details
Product Name	4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile
CAS No.	214360-44-8
Molecular Formula	C13H16BNO2
Molecular Weight	229.08 g/mol
Synonyms	4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile; 4-Cyanophenylboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (common mis-assignment, verify structure); 4-Boronobenzonitrile pinacol ester; 4-CN-PhBpin; Pinacol 4-cyanophenylboronate; 2-(4-Cyanophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.