Description

2'-Amino-5'-Chloro-2,2,2-Trifluoroacetophenone is a high-purity, halogenated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique trifluoromethyl and amino-chloro substitution pattern makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into complex molecules to modulate their properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized colorants and photographic chemicals.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	2'-Amino-5'-Chloro-2,2,2-Trifluoroacetophenone
CAS No.	214353-17-0
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone; 2-Amino-5-chloro-α,α,α-trifluoroacetophenone; 2'-Amino-5'-chloro-α,α,α-trifluoroacetophenone; 5-Chloro-2-amino-α,α,α-trifluoroacetophenone; 2-Amino-5-chlorobenzotrifluoride ketone; 2,2,2-Trifluoro-1-(2-amino-5-chlorophenyl)ethanone; ACFK Intermediate; Trifluoroacetyl-m-chloroaniline derivative
EINECS	Contact for details

Quality Control

Every batch of 2'-Amino-5'-Chloro-2,2,2-Trifluoroacetophenone is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure compliance with stringent industry standards for purity and identity. Certificates of Analysis (COA) detailing all test results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.