Description

Carbamic Acid, [(3S,4S)-4-Fluoro-3-Pyrrolidinyl]-, 1,1-Dimethylethyl Ester (9Ci) is a high-purity, stereochemically defined fluorinated pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected, fluorinated amine scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated analogs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially protease inhibitors and kinase inhibitors.
• Agrochemical Research: Used in the development of advanced, fluorinated active ingredients for crop protection with improved efficacy and environmental profile.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to introduce fluorine atoms at specific positions to modulate potency, selectivity, and ADMET properties.
• Process Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of GMP manufacturing routes for clinical and commercial APIs.
• Fluorine Chemistry: A valuable reagent for exploring new fluorination methodologies and constructing fluorinated heterocycles and alicyclic systems.

Basic Information

Item	Detail
Product Name	Carbamic Acid, [(3S,4S)-4-Fluoro-3-Pyrrolidinyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	213388-72-8
Molecular Formula	C9H17FN2O2
Molecular Weight	204.24 g/mol
Synonyms	(3S,4S)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-3-carboxylic acid; tert-Butyl (3S,4S)-4-fluoro-3-pyrrolidinecarboxylate; (3S,4S)-4-Fluoro-N-Boc-pyrrolidine-3-carboxylic acid; Boc-(3S,4S)-4-Fluoro-D-proline; (3S,4S)-1-Boc-4-fluoropyrrolidine-3-carboxylic acid; (3S,4S)-4-Fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(3S,4S)-4-Fluoro-3-Pyrrolidinyl]-, 1,1-Dimethylethyl Ester adheres to stringent internal quality standards, ensuring high chemical and chiral purity for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as assay, enantiomeric excess, and impurity profiles. We are committed to consistent quality and supply reliability, with specifications that can meet the needs of research through to development scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.