Description

Rhodium(1+), [(1,2,5,6-η)-1,5-Cyclooctadiene][(2R,2'R,5R,5'R)-1,1'-(1,2-Ethanediyl)Bis[2,5-Diethylphospholane-κp]]-, Tetrafluoroborate(1-) (1:1) is a high-value, chiral rhodium-based organometallic complex designed for advanced asymmetric catalysis. This compound is a highly efficient and selective catalyst precursor, enabling the synthesis of enantiomerically pure compounds critical to modern pharmaceuticals and fine chemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for hydrogenation and other asymmetric transformations.

Application

• Asymmetric Hydrogenation Catalyst: A key precursor for the enantioselective hydrogenation of prochiral olefins, enamides, and ketones in pharmaceutical intermediate synthesis.
• Pharmaceutical Manufacturing: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Fine Chemical Production: Facilitates the synthesis of complex, high-value fragrance and flavor ingredients, as well as advanced materials.
• Academic & Industrial Research: Serves as a benchmark catalyst in method development and discovery chemistry for new asymmetric reactions.
• Process Chemistry Optimization: Employed in scaling up laboratory synthetic routes to commercial manufacturing processes with high enantiomeric excess (ee).

Basic Information

Product Name	Rhodium(1+), [(1,2,5,6-η)-1,5-Cyclooctadiene][(2R,2'R,5R,5'R)-1,1'-(1,2-Ethanediyl)Bis[2,5-Diethylphospholane-κp]]-, Tetrafluoroborate(1-) (1:1)
CAS No.	213343-66-9
Molecular Formula	C26H48BF4P2Rh
Molecular Weight	612.31 g/mol
Synonyms	[(COD)Rh(Et-DuPHOS)]BF4; (1,5-Cyclooctadiene)rhodium(I) (R,R)-1,2-bis(2,5-diethylphospholano)ethane tetrafluoroborate; Rh(Et-DuPHOS)(COD)BF4; Rhodium(I)-(R,R)-Et-DuPHOS-COD tetrafluoroborate; (R,R)-Et-DuPHOS Rh(COD)BF4; Asymmetric hydrogenation catalyst Rh-Et-DuPHOS; [Rh((R,R)-Et-DuPHOS)(COD)]BF4; DuPHOS rhodium catalyst
EINECS	Contact for details

Quality Control

Our high-purity catalyst precursors are manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. For long-term storage, keep the primary container in a desiccator.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Rhodium Content	16.0 - 17.0 %
Solubility	Soluble in dichloromethane, acetone; slightly soluble in methanol
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.