Description

Carbamic Acid, (3R,6S)-1,4-Dioxaspiro[2.3]Hex-6-Yl-, 1,1-Dimethylethyl Ester is a specialized chiral building block featuring a spirocyclic acetal-protected diol moiety. This compound is of significant value in pharmaceutical research and development as a key intermediate for the synthesis of complex, biologically active molecules. It is primarily sought after by fine chemical manufacturers and R&D laboratories engaged in the production of novel therapeutics, particularly those requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Utilized in the construction of complex molecular architectures where the (3R,6S) stereochemistry is essential for biological activity.
• Medicinal Chemistry Research: Employed as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	Carbamic Acid, (3R,6S)-1,4-Dioxaspiro[2.3]Hex-6-Yl-, 1,1-Dimethylethyl Ester
CAS No.	213339-05-0
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(3R,6S)-1,4-Dioxaspiro[2.3]hex-6-ylcarbamic acid tert-butyl ester; tert-Butyl N-[(3R,6S)-1,4-dioxaspiro[2.3]hex-6-yl]carbamate; (3R,6S)-6-[(tert-Butoxycarbonyl)amino]-1,4-dioxaspiro[2.3]hexane; BOC-Protected (3R,6S)-1,4-Dioxaspiro[2.3]hex-6-ylamine; (3R,6S)-1,4-Dioxaspiro[2.3]hexane-6-carbamic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.