Description

n-Boc-Indole-2-Boronic Acid CAS NO 213318-44-6 is a high-purity, protected boronic acid derivative essential for modern synthetic organic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex indole-based molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid partner for constructing biaryl and heterobiaryl systems under mild conditions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with indole scaffolds.
• Material Science: Employed in the creation of organic semiconductors, ligands for catalysis, and functional polymers.
• Academic & Contract Research: A valuable reagent for methodology development and library synthesis in academic and CRO laboratories.
• Peptide Mimetics & PROTACs: Facilitates the introduction of indole motifs into complex molecules like peptide mimetics and proteolysis-targeting chimeras.

Basic Information

Product Name	n-Boc-Indole-2-Boronic Acid
CAS No.	213318-44-6
Molecular Formula	C₁₃H₁₆BNO₄
Molecular Weight	261.09 g/mol
Synonyms	2-Borono-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; 1-Boc-indole-2-boronic acid; tert-Butyl 2-borono-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-1H-indole-2-boronic acid; N-Boc-2-indoleboronic acid; Boc-Indole-2-B(OH)₂; 1-Boc-2-indolylboronic acid; 2-Boron-N-Boc-indole
EINECS	Contact for details

Quality Control

Our n-Boc-Indole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. For custom synthesis or specific pharmacopeial standards (e.g., USP, EP), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.