Description

(R)-4-Tosyloxy-1,2-Epoxybutane is a high-value chiral epoxide building block, essential for the stereoselective synthesis of complex bioactive molecules. Its unique structure, featuring both a reactive epoxide ring and a tosylate leaving group, makes it a versatile intermediate for constructing chiral centers with defined (R) configuration. This compound is critically needed by pharmaceutical R&D and fine chemical manufacturers for producing active pharmaceutical ingredients (APIs), chiral ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-blockers, antiviral agents, and other optically active drugs.
• Asymmetric Synthesis: Used in nucleophilic ring-opening reactions to introduce chiral 1,2-amino alcohols or 1,2-diol functionalities.
• Ligand and Catalyst Preparation: Building block for the development of chiral auxiliaries, catalysts, and resolving agents.
• Agrochemical Research: Intermediate in the synthesis of chiral pesticides and herbicides.
• Material Science: Precursor for chiral polymers and advanced functional materials.
• Academic & Process Chemistry: Valuable reagent for methodological development and scale-up studies in organic synthesis.

Basic Information

Product Name	(R)-4-Tosyloxy-1,2-Epoxybutane
CAS No.	213262-97-6
Molecular Formula	C11H14O4S
Molecular Weight	242.29 g/mol
Synonyms	(R)-(-)-4-(p-Toluenesulfonyloxy)-1,2-epoxybutane; (R)-4-(p-Tolylsulfonyloxy)-1,2-epoxybutane; (R)-1,2-Epoxy-4-(tosyloxy)butane; (R)-Tosyl Glycidyl Ether; (2R)-Oxiran-2-ylmethyl 4-methylbenzenesulfonate; (R)-Glycidyl Tosylate; (R)-GT; (R)-Epibromohydrin Tosylate Analog
EINECS	Contact for details

Quality Control

Our (R)-4-Tosyloxy-1,2-Epoxybutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.