Description

L-Norvaline, 5-Borono- (9Ci) is a specialized non-proteinogenic amino acid derivative featuring a boronic acid functional group. This compound is of significant interest in medicinal chemistry and drug discovery due to its role as a key building block and intermediate for the synthesis of proteasome inhibitors and other biologically active molecules. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of novel therapeutics and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of boronic acid-based proteasome inhibitors, such as bortezomib analogs, for oncology research.
• Bioconjugation & Probe Development: Used in the creation of biochemical probes and affinity ligands for studying enzyme activity and protein-protein interactions.
• Peptidomimetic Chemistry: Serves as a building block for designing and synthesizing peptide mimics with enhanced stability and biological activity.
• Organic Synthesis Reagent: Employed in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions as a boronic acid coupling partner.
• Biochemical Research: Utilized in academic and industrial research focused on amino acid metabolism, enzyme inhibition, and signal transduction pathways.
• API Development: Investigated as an intermediate in the development of Active Pharmaceutical Ingredients (APIs) targeting specific disease mechanisms.

Basic Information

Product Name	L-Norvaline, 5-Borono- (9Ci)
CAS No.	212839-30-0
Molecular Formula	C5H12BNO4
Molecular Weight	160.97 g/mol
Synonyms	5-Borono-L-norvaline; L-2-Amino-5-boronopentanoic acid; (S)-2-Amino-5-boronopentanoic acid; Bortezomib Intermediate; Norvaline boronic acid; Proteasome inhibitor intermediate; (S)-5-Borononorvaline; 212839-30-0
EINECS	Contact for details

Quality Control

Our L-Norvaline, 5-Borono- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.