Description

Dichloro[(R)-(+)-2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl][(1S,2S)-(-)-1,2-Diphenylethylenediamine]Ruthenium (II) is a highly sophisticated chiral ruthenium complex that serves as a premier catalyst for asymmetric hydrogenation and other enantioselective transformations. Its value lies in enabling the production of single-enantiomer intermediates with exceptional optical purity, which is critical for the efficacy and safety of advanced pharmaceuticals. This catalyst is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance tools for constructing complex chiral molecules.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral ketones, olefins, and imines to produce chiral alcohols, amines, and other building blocks.
• Pharmaceutical Intermediate Synthesis: Key for manufacturing active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee), such as certain antibiotics, antivirals, and cardiovascular drugs.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators where biological activity is enantiomer-specific.
• Fine Chemical and Fragrance Synthesis: Enables the creation of enantiomerically pure flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Employed for scaling up efficient and selective catalytic routes in pilot plants and commercial manufacturing.

Basic Information

Product Name	Dichloro[(R)-(+)-2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl][(1S,2S)-(-)-1,2-Diphenylethylenediamine]Ruthenium (II)
CAS No.	212210-87-2
Molecular Formula	C56H48Cl2N2P2Ru
Molecular Weight	968.92 g/mol
Synonyms	RuCl2[(R)-BINAP][(1S,2S)-DPEN]; (R)-BINAP/(1S,2S)-DPEN-Ru(II) Dichloride; Noyori-Ikariya Catalyst; [RuCl2((R)-binap)((1S,2S)-dpen)]; Ruthenium(II) dichloride (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (1S,2S)-(-)-1,2-diphenylethylenediamine; Asymmetric Hydrogenation Catalyst (BINAP/DPEN-Ru); Ru-BINAP-DPEN complex
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalysts is produced and tested under strict quality management protocols to ensure consistent high performance and purity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, chiral purity, and residual solvent content. Our quality systems support compliance with cGMP standards for pharmaceutical applications, and we welcome audits and specific testing requests to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent decomposition. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Residual Solvents (GC)	Meets ICH guidelines
Chloride Content	Conforms to theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.