Description

4,4,4-Trifluoro-Butane-1-Sulfonyl Chloride is a high-purity organofluorine building block and a versatile sulfonylating agent. This compound is critical for introducing the trifluorobutylsulfonyl moiety, a key functional group that can enhance the metabolic stability and binding affinity of target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated chain imparts improved lipophilicity and biological activity.
• Material Science: Serves as a monomer or modifier in the production of specialty polymers and coatings with unique surface properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for introducing sulfonyl chloride groups with a fluorinated tail.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	4,4,4-Trifluoro-Butane-1-Sulfonyl Chloride
CAS No.	212190-25-5
Molecular Formula	C4H6ClF3O2S
Molecular Weight	210.60 g/mol
Synonyms	1-Butanesulfonyl chloride, 4,4,4-trifluoro-; 4,4,4-Trifluorobutane-1-sulfonyl chloride; 4,4,4-Trifluorobutylsulfonyl chloride; 4,4,4-Trifluoro-1-butanesulfonyl chloride; 212190-25-5; 4,4,4-Trifluorobutanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-Butane-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP and ISO compliant production for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.