Description

1-Boc-2,5-Dihydro-1H-Pyrrole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrole ring and a boronic ester functional group. This compound is critical for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone of modern medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex heterocyclic structures.
• Material Science & Organic Electronics: Employed in the synthesis of organic semiconductors, conductive polymers, and advanced functional materials.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates for studying biological processes.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	1-Boc-2,5-Dihydro-1H-Pyrrole-3-Boronic Acid, Pinacol Ester
CAS No.	212127-83-8
Molecular Formula	C15H26BNO4
Molecular Weight	295.19 g/mol
Synonyms	1-Boc-2,5-Dihydro-1H-pyrrole-3-boronic acid pinacol ester; 1-(tert-Butoxycarbonyl)-2,5-dihydro-1H-pyrrole-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate; 1-Boc-3,4-didehydropyrrolidine-3-boronic acid pinacol ester; N-Boc-2,5-dihydro-1H-pyrrole-3-boronic acid pinacol ester; 3-Borono-1-Boc-2,5-dihydro-1H-pyrrole pinacol ester.
EINECS	Contact for details

Quality Control

Our 1-Boc-2,5-Dihydro-1H-Pyrrole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal quality standards and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.