Description

3,6-Dihydropyran-5-Boronic Ester is a versatile and valuable organoboron building block, specifically a cyclic vinyl boronic ester derivative. Its primary value lies in its role as a key intermediate in modern synthetic organic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for drug discovery, catalyst development, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for creating complex heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a pivotal coupling partner for the formation of carbon-carbon bonds, a fundamental transformation in medicinal and process chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and novel polymers.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates due to the reactivity of the boronic ester functional group.
• Academic & Industrial R&D: A staple reagent in laboratories focused on methodology development and complex molecule synthesis.

Basic Information

Product Name	3,6-Dihydropyran-5-Boronic Ester
CAS No.	212127-81-6
Molecular Formula	C9H15BO3 (Typical for pinacol ester)
Molecular Weight	182.03 g/mol (for pinacol ester form)
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyran; 3,6-Dihydro-2H-pyran-5-ylboronic acid pinacol ester; 2-(3,6-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Boronic ester-3,6-dihydro-2H-pyran; DHP-BPin; Vinyl boronic ester pyran derivative.
EINECS	Contact for details

Quality Control

Every batch of our 3,6-Dihydropyran-5-Boronic Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by NMR/HPLC), identity confirmation, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for traceability and consistency, making it suitable for demanding pharmaceutical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient air during use. Optimal storage temperature is 2-8°C (refrigerated) for extended shelf-life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Purity (NMR)	≥95%
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.