Description

[(1S)-2-(1,1-Dimethylethoxy)-1-Formylethyl]Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester is a sophisticated, optically active chemical building block primarily used in advanced organic synthesis. This compound matters for its role as a key protected intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is essential for chemists and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, specialized intermediates for peptide synthesis and chiral drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for chiral drugs.
• Peptide Synthesis: Used as a protected amino aldehyde derivative in solid-phase and solution-phase peptide chemistry.
• Chiral Synthesis: Serves as a source of chirality for constructing complex, stereochemically defined molecular architectures.
• Protecting Group Chemistry: The Fmoc (9-fluorenylmethoxycarbonyl) and tert-butyloxycarbonyl (Boc) like protecting groups make it valuable for orthogonal deprotection strategies in complex syntheses.
• Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.
• Bioconjugation: Potential use in the synthesis of linker molecules for antibody-drug conjugates (ADCs) and other bioconjugates.

Basic Information

Product Name	[(1S)-2-(1,1-Dimethylethoxy)-1-Formylethyl]Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester
CAS No.	211929-87-2
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-L-Serinal acetonide; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethyl-4-oxobutanal; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serinal acetonide; Fmoc-Ser(Acetonide)-H; Fmoc-L-Ser(Acetonide)-H; Nα-Fmoc-L-serinal acetonide; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethyl-4-oxobutyraldehyde; L-Serinal, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, cyclic acetal with acetone
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific impurity profiles are provided with each shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.