Description

(R)-4-tert-Butoxy-2-Ethyl-4-Oxobutanoic Acid CAS NO 210048-05-8 is a high-purity chiral intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant value in the synthesis of complex molecules where precise stereocontrol is essential for biological activity or material properties. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications such as the development of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder drugs.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce the (R)-configuration into target molecules.
• Peptidomimetics Research: Serves as a constrained amino acid analog in the design and synthesis of novel peptide-like compounds for drug discovery.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for transition metal catalysis or organocatalysts.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, agrochemicals, and flavors & fragrances requiring high enantiomeric purity.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic chemistry and for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	(R)-4-tert-Butoxy-2-Ethyl-4-Oxobutanoic Acid
CAS No.	210048-05-8
Molecular Formula	C10H18O4
Molecular Weight	202.25 g/mol
Synonyms	(R)-4-(tert-Butoxy)-2-ethyl-4-oxobutanoic acid; (R)-2-Ethyl-4-(tert-butoxy)-4-oxobutanoic acid; (R)-4-tert-Butoxy-2-ethyl-4-oxobutyric acid; (R)-HOTeb; (R)-Ethylsuccinic acid tert-butyl ester derivative; (R)-2-Ethyl-4-oxo-4-(tert-butoxy)butanoic acid; (R)-α-Ethyl-β-tert-butoxycarbonylpropionic acid
EINECS	Contact for details

Quality Control

Our (R)-4-tert-Butoxy-2-Ethyl-4-Oxobutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and production use. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.