Description

4-Penten-1-One, 2,2-Difluoro-3-Hydroxy-1-Phenyl- (9Ci) is a specialized fluorinated organic building block with a unique α,β-unsaturated ketone structure bearing both hydroxyl and phenyl substituents. This compound is valued for its role as a key chiral intermediate in advanced pharmaceutical synthesis, enabling the introduction of difluoromethylene and other functional groups critical for modulating drug metabolism and potency. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anti-inflammatory, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in creating novel herbicides and pesticides where the difluoro and ketone functionalities contribute to biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or surface properties.
• Ligand Synthesis: Employed in the preparation of novel chiral ligands for asymmetric catalysis, enhancing enantioselectivity in critical synthetic transformations.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination reactions and the behavior of fluorinated enones in organic synthesis.

Basic Information

Product Name	4-Penten-1-One, 2,2-Difluoro-3-Hydroxy-1-Phenyl- (9Ci)
CAS No.	209474-41-9
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	2,2-Difluoro-3-hydroxy-1-phenyl-4-penten-1-one; 1-Phenyl-2,2-difluoro-3-hydroxy-4-penten-1-one; 3-Hydroxy-2,2-difluoro-1-phenyl-4-penten-1-one; α,α-Difluoro-β-hydroxy-γ-phenyl-γ,δ-unsaturated ketone; (E/Z)-2,2-Difluoro-3-hydroxy-1-phenylpent-4-en-1-one; DFHPK (abbreviation); Fluorinated phenyl hydroxy enone
EINECS	Contact for details

Quality Control

Our 4-Penten-1-One, 2,2-Difluoro-3-Hydroxy-1-Phenyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.