Description

1H-Imidazole, 4,5-Dihydro-2-[4-(Trifluoromethyl)Phenyl]- is a specialized heterocyclic organic compound featuring a dihydroimidazole core substituted with a trifluoromethylphenyl group. This structure makes it a valuable key intermediate and building block in advanced organic synthesis, particularly for pharmaceuticals and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Acts as a precursor for nitrogen-containing ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs, due to its conjugated system.
• Chemical Biology Probe: Utilized in medicinal chemistry to develop molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Item	Detail
Product Name	1H-Imidazole, 4,5-Dihydro-2-[4-(Trifluoromethyl)Phenyl]-
CAS No.	208718-17-6
Molecular Formula	C10H9F3N2
Molecular Weight	214.19 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole; 4,5-Dihydro-2-[4-(trifluoromethyl)phenyl]-1H-imidazole; 2-(4-Trifluoromethylphenyl)-2-imidazoline; 2-(4-Trifluoromethylphenyl)-4,5-dihydro-1H-imidazole; 2-(α,α,α-Trifluoro-p-tolyl)-2-imidazoline; 1H-Imidazole, 4,5-dihydro-2-[4-(trifluoromethyl)phenyl]-; 208718-17-6; 4,5-Dihydro-2-(4-trifluoromethylphenyl)imidazole
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole, 4,5-Dihydro-2-[4-(Trifluoromethyl)Phenyl]- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our facilities operate under cGMP principles where applicable, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.