Description

(R)-Boroabu-(+)-Pinanediol-Cf3Co2H is a high-value, chiral organoboron reagent featuring a trifluoromethylated carboxylic acid moiety. This compound matters as a sophisticated building block for introducing chiral centers and fluorinated groups into complex molecules, which is critical for modulating the biological activity and metabolic stability of pharmaceuticals. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthetic applications, including asymmetric synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Asymmetric Synthesis: Employed in Suzuki-Miyaura and other transition-metal-catalyzed cross-coupling reactions to construct stereodefined carbon-carbon bonds.
• Fluorine Chemistry: Serves as a specialized reagent for incorporating the trifluoromethyl (CF3) group, a privileged motif in medicinal chemistry that enhances lipophilicity and metabolic stability.
• Agrochemical Research: Used in the development of novel herbicides and pesticides where chirality and fluorine atoms are crucial for efficacy and environmental profile.
• Material Science: Potential application as a monomer or additive in the synthesis of advanced polymers with specific optical or electronic properties.
• Academic & Contract Research: A valuable tool for methodology development and exploring new reaction pathways in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	(R)-Boroabu-(+)-Pinanediol-Cf3Co2H
CAS No.	208521-43-1
Molecular Formula	C₁₈H₂₈BF₃O₄
Molecular Weight	376.22 g/mol
Synonyms	(R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,3,3-trifluoropropanoic Acid; (R)-Boro-tert-leucine-CF3-CO2H; (R)-3,3,3-Trifluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoic Acid; (R)-BoroAbu(CF3)OH; (R)-α-(Trifluoromethyl)-B-boronoalanine derivative; Pinanediol ester of (R)-Boro-trifluoromethylalanine; (R)-Boro-trifluoromethyl alanine pinanediol ester; (R)-BoroAbu(CF3)CO2H Pinacol Ester
EINECS	Contact for details

Quality Control

Every batch of (R)-Boroabu-(+)-Pinanediol-Cf3Co2H is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and chiral analysis to ensure identity, purity, and enantiomeric excess meet the stringent requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment. Due to its hygroscopic and easily oxidized nature, the container should only be opened in a controlled, moisture-free atmosphere and resealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.