Description

4'-Fluoro-3'-(trifluoromethyl)acetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for creating compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This product is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine motifs contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance and surface properties.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reactions and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	4'-Fluoro-3'-(trifluoromethyl)acetophenone
CAS No.	208173-24-4
Molecular Formula	C9H4F4O
Molecular Weight	204.12 g/mol
Synonyms	1-[4-Fluoro-3-(trifluoromethyl)phenyl]ethanone; 4-Fluoro-α,α,α-trifluoro-m-acetophenone; 3'-Trifluoromethyl-4'-fluoroacetophenone; 4-Fluoro-3-trifluoromethylacetophenone; 4-Fluoro-α,α,α-trifluoro-3-methylacetophenone; 1-(4-Fluoro-3-(trifluoromethyl)phenyl)ethan-1-one; m-Trifluoromethyl-p-fluoroacetophenone
EINECS	Contact for details

Quality Control

Every batch of 4'-Fluoro-3'-(trifluoromethyl)acetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.