Description

4'-Fluoro-2'-(trifluoromethyl)acetophenone is a high-value fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique trifluoromethyl and fluoro substituents make it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex molecules for drug discovery, particularly in creating compounds with enhanced bioavailability and target selectivity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to the desired electronic and physical properties.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as a versatile electrophile or precursor for further functionalization in academic and industrial research laboratories.

Basic Information

Product Name	4'-Fluoro-2'-(trifluoromethyl)acetophenone
CAS No.	208173-21-1
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-[4-Fluoro-2-(trifluoromethyl)phenyl]ethanone; 4'-Fluoro-α,α,α-trifluoro-2-acetophenone; 2-Acetyl-5-fluorobenzotrifluoride; 4-Fluoro-2-(trifluoromethyl)acetophenone; 2-(Trifluoromethyl)-4-fluoroacetophenone; 4-Fluoro-α,α,α-trifluoro-o-acetophenone; FTA; Contact for additional names.
EINECS	Contact for details

Quality Control

Every batch of 4'-Fluoro-2'-(trifluoromethyl)acetophenone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by validated methods (HPLC, GC, NMR).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥98.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.