Description

1,3-Dibromo-5-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and a trifluoromethoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling more efficient and selective chemical transformations.
• Functional Material Precursor: Employed in the synthesis of organic electronic materials, such as charge-transport layers for OLEDs and semiconductors, due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing molecular libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1,3-Dibromo-5-(Trifluoromethoxy)Benzene
CAS No.	207226-31-1
Molecular Formula	C7H3Br2F3O
Molecular Weight	343.90 g/mol
Synonyms	3,5-Dibromophenyl trifluoromethyl ether; 5-(Trifluoromethoxy)-1,3-dibromobenzene; 1,3-Dibromo-5-(trifluoromethoxy)benzene; Benzene, 1,3-dibromo-5-(trifluoromethoxy)-; 3,5-Dibromo(trifluoromethoxy)benzene; 3,5-Dibromo-alpha,alpha,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 1,3-Dibromo-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is subjected to rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.