Description

D-Phenylalanine, 3,3,3-Trichloro-n-[(1R)-2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]Alanyl-, Methyl Ester (9Ci) is a specialized, high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering precise stereochemical control for research and development. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other high-value synthetic targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptidomimetics, where its specific stereochemistry and functional groups are essential for biological activity.
• Asymmetric Synthesis: Serves as a sophisticated building block in catalytic and stoichiometric asymmetric synthesis for constructing molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	D-Phenylalanine, 3,3,3-Trichloro-n-[(1R)-2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]Alanyl-, Methyl Ester (9Ci)
CAS No.	206748-70-1
Molecular Formula	C22H23Cl3N2O5
Molecular Weight	501.78 g/mol
Synonyms	Methyl (2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3,3,3-trichloropropanoyl]amino]-3-phenylpropanoate; (R)-Methyl 2-((R)-2-((R)-2-amino-3-phenylpropanamido)-3,3,3-trichloropropanamido)-3-phenylpropanoate; D-Phenylalanine, N-[3,3,3-trichloro-1-[[(1R)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-1-oxopropyl]-, methyl ester; A Chiral Trichloroalanine Derivative; Advanced Pharmaceutical Intermediate 206748-70-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.