Description

(2R,3S)-1-Carboxy-4-Trifluoromethyl-2,3-Dihydroxycyclohexa-4,6-Diene, 95 is a high-purity, chiral fluorinated dihydroxycyclohexadiene carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique stereochemistry and the presence of the trifluoromethyl group, which are essential for imparting desirable properties like metabolic stability and lipophilicity in target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in developing new generations of herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated for incorporation into specialty polymers and advanced organic frameworks to modify thermal and chemical resistance properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and biological pathways due to its fluorinated tag.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of fluorinated fine chemicals.

Basic Information

Product Name	(2R,3S)-1-Carboxy-4-Trifluoromethyl-2,3-Dihydroxycyclohexa-4,6-Diene, 95
CAS No.	205985-94-0
Molecular Formula	C9H7F3O5
Molecular Weight	252.14 g/mol
Synonyms	1-Carboxy-4-(trifluoromethyl)-2,3-dihydroxycyclohexa-4,6-diene; (2R,3S)-4-(Trifluoromethyl)cyclohexa-4,6-diene-1,2,3-triol-1-carboxylic Acid; 4-Trifluoromethylshikimic Acid Derivative; (2R,3S)-1,2,3-Trihydroxy-4-(trifluoromethyl)cyclohexa-4,6-diene-1-carboxylic Acid; Fluorinated Shikimate Analog; (2R,3S)-4-CF3-1,2,3-Trihydroxycyclohexa-4,6-diene-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (2R,3S)-1-Carboxy-4-Trifluoromethyl-2,3-Dihydroxycyclohexa-4,6-Diene, 95 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific rotation are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. The compound is hygroscopic (moisture-sensitive); therefore, containers should be sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.