Description

2-Pyridinemethanol, α-(1,2-Difluoroethenyl)-, (Z)- (9Ci) is a specialized fluorinated pyridine derivative, a high-value intermediate in advanced organic synthesis. Its unique structure, featuring a (Z)-configured difluoroethenyl side chain, makes it a critical building block for constructing complex molecules with precise stereochemistry and fluorine substitution. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients requiring specific fluorination patterns for enhanced efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms contribute to improved biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials that benefit from fluorinated aromatic systems.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination reactions and the properties of vinyl fluorides in medicinal chemistry.

Basic Information

Product Name	2-Pyridinemethanol, α-(1,2-Difluoroethenyl)-, (Z)- (9Ci)
CAS No.	205878-02-0
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	(Z)-α-(1,2-Difluoroethenyl)-2-pyridinemethanol; (Z)-[2-(1,2-Difluorovinyl)pyridin-3-yl]methanol; (Z)-3-(Hydroxymethyl)-2-(1,2-difluorovinyl)pyridine; 2-Pyridinemethanol, α-(1,2-difluoroethenyl)-, (Z)-; (Z)-1-(1,2-Difluoroethenyl)-2-(hydroxymethyl)pyridine; (Z)-2-(1,2-Difluorovinyl)-3-pyridinemethanol
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridinemethanol, α-(1,2-Difluoroethenyl)-, (Z)- (9Ci) is produced and analyzed under strict quality management protocols. We ensure compliance with the stringent purity requirements demanded for advanced synthetic intermediates. Comprehensive analytical testing, including chiral purity verification, is performed. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (Z-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.