Description

2-Methoxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde is a specialized photoaffinity labeling reagent featuring a reactive diazirine group and an aldehyde functional handle. This compound is critical for advanced biochemical research, enabling the covalent cross-linking and identification of biomolecular interaction sites. It is primarily utilized by pharmaceutical R&D teams, chemical biologists, and academic researchers in proteomics and drug discovery.

Application

• Photoaffinity Labeling (PAL): A key reagent for irreversible photo-crosslinking to probe protein-ligand, protein-protein, and protein-nucleic acid interactions.
• Chemical Biology Probes: Used to synthesize bifunctional probes where the aldehyde group allows for conjugation to reporter tags (e.g., biotin, fluorophores) or solid supports.
• Target Identification & Validation: Essential in drug discovery for mapping the binding sites of small molecule drugs or candidate compounds within complex biological systems.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) to identify and characterize enzymes and their active sites.
• Material Science Functionalization: The diazirine group can be used to modify surfaces or polymers under UV light for creating advanced functional materials.

Basic Information

Product Name	2-Methoxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde
CAS No.	205485-25-2
Molecular Formula	C10H7F3N2O2
Molecular Weight	244.17 g/mol
Synonyms	4-Formyl-2-methoxyphenyl 3-(trifluoromethyl)-3H-diazirine; 3-(Trifluoromethyl)-3-(4-formyl-2-methoxyphenyl)diazirine; 2-Methoxy-4-(3-(trifluoromethyl)diazirin-3-yl)benzaldehyde; Photoaffinity Labeling Benzaldehyde Derivative; Diazirine-Benzaldehyde Crosslinker; TFMD Benzaldehyde; PAL Reagent Aldehyde
EINECS	Contact for details

Quality Control

Our production of 2-Methoxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde adheres to stringent quality protocols to ensure batch-to-batch consistency and high reactivity for sensitive research applications. Each lot is fully characterized and supplied with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We support research and development under ISO 9001 quality management principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.