Description

3-(3-Methoxyphenyl)-3-(Trifluoromethyl)-3H-Diazirine is a specialized diazirine-based photoaffinity labeling reagent, a critical tool for advanced biochemical and pharmaceutical research. Its core value lies in its ability to form highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and identification of biomolecular interaction sites. This compound is essential for researchers and developers in proteomics, drug discovery, and chemical biology who require precise mapping of protein-ligand and protein-protein interactions.

Application

• Photoaffinity Labeling (PAL): Covalent tagging of small molecule ligands to their biological targets (e.g., proteins, nucleic acids) for target identification and validation in drug discovery pipelines.
• Proteomics Research: Mapping binding sites and studying the structure-activity relationships (SAR) of bioactive compounds within complex biological systems.
• Chemical Biology Probes: Development of activity-based probes (ABPs) to visualize and quantify enzyme activity or protein function in live cells.
• Material Science Surface Modification: Photochemical grafting onto polymer surfaces to introduce specific functional groups for advanced material applications.
• Cross-linking Studies: Investigation of transient or weak biomolecular complexes that are difficult to study by conventional methods.

Basic Information

Product Name	3-(3-Methoxyphenyl)-3-(Trifluoromethyl)-3H-Diazirine
CAS No.	205485-24-1
Molecular Formula	C10H7F3N2O
Molecular Weight	228.17 g/mol
Synonyms	3-(3-Methoxyphenyl)-3-(trifluoromethyl)diazirine; 3-(m-Methoxyphenyl)-3-(trifluoromethyl)diazirine; 3-Methoxy-α,α,α-trifluoro-3H-diazirin-3-ylbenzene; 3-(Trifluoromethyl)-3-(3-methoxyphenyl)diazirine; 3-(3-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine; m-Methoxyphenyl(trifluoromethyl)diazirine; Photoaffinity Labeling Reagent 3-Methoxy; PAL Reagent 3-Methoxy
EINECS	Contact for details

Quality Control

Our 3-(3-Methoxyphenyl)-3-(Trifluoromethyl)-3H-Diazirine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures between -20°C to -10°C for long-term stability. This compound is light-sensitive (store away from light). Allow the container to reach ambient temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.