Description

4-[(4R,5R)-Fmoc-4-Methyl-1,3-Dioxan-2-Yl]Benzoic Acid is a sophisticated, stereochemically defined building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chiral intermediates to construct complex molecular architectures. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Peptide Synthesis: Serves as a key, protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS), particularly for introducing specific, non-natural amino acid motifs.
• Pharmaceutical Research: Used as a chiral building block in the research and development of new drug candidates, especially those targeting complex biological pathways.
• Combinatorial Chemistry: A valuable reagent for creating diverse chemical libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: Can be employed in the synthesis of linker molecules or modified biomolecules for targeted drug delivery systems and diagnostic probes.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and carbohydrate chemistry.
• Process Chemistry: Acts as an intermediate in the scalable synthesis of complex target molecules, where stereochemical integrity is paramount.

Basic Information

Product Name	4-[(4R,5R)-Fmoc-4-Methyl-1,3-Dioxan-2-Yl]Benzoic Acid
CAS No.	205109-16-6
Molecular Formula	C28H26O6
Molecular Weight	458.50 g/mol
Synonyms	Fmoc-4-Methyl-1,3-dioxane benzoic acid derivative; (4R,5R)-4-Methyl-2-(4-carboxyphenyl)-1,3-dioxane-4,5-diyl bis(9H-fluorene-9-carboxylate); 4-[(4R,5R)-4-Methyl-2-(9H-fluoren-9-ylmethoxycarbonyl)-1,3-dioxan-2-yl]benzoic acid; 9-Fluorenylmethyl (4R,5R)-4-methyl-2-(4-carboxyphenyl)-1,3-dioxane-4,5-dicarboxylate; Fmoc-protected dioxane benzoic acid; Chiral dioxane-Fmoc building block.
EINECS	Contact for details

Quality Control

Our production of 4-[(4R,5R)-Fmoc-4-Methyl-1,3-Dioxan-2-Yl]Benzoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Long-term storage is recommended at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.