Description

(+)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Tetrafluoroborate is a high-purity, chiral organorhodium complex widely recognized as a highly efficient and selective asymmetric hydrogenation catalyst. Its primary value lies in enabling the production of enantiomerically pure intermediates critical for advanced pharmaceutical and fine chemical synthesis. This catalyst is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their processes. The compound is supplied with a guaranteed CAS number of 205064-10-4.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Key in the production of active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee), such as chiral β-amino acids and lactams.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of complex, high-value fragrance and flavor compounds with specific stereochemistry.
• Academic & Industrial R&D: A benchmark catalyst for developing new asymmetric synthetic methodologies and process optimization.
• Chiral Ligand Evaluation: Serves as a precursor or comparative standard for testing new chiral phosphine ligands in transition metal catalysis.

Basic Information

Product Name	(+)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Tetrafluoroborate
CAS No.	205064-10-4
Molecular Formula	C26H40BF4P2Rh
Molecular Weight	580.25 g/mol
Synonyms	(S,S)-Me-DuPhos Rhodium(I) Tetrafluoroborate COD Complex; [Rh((S,S)-Me-DuPhos)(COD)]BF4; (S,S)-1,2-Bis(2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Rh-Me-DuPhos Catalyst; DuPhos-Rh Catalyst; (S,S)-Me-DuPhos-Rh(COD)BF4; Asymmetric Hydrogenation Catalyst (Me-DuPhos Rhodium); (2S,2'S,5S,5'S)-1,1'-(1,2-Phenylene)bis(2,5-dimethylphospholane)(1,5-cyclooctadiene)rhodium tetrafluoroborate
EINECS	Contact for details

Quality Control

Every batch of our (+)-1,2-Bis((2S,5S)-2,5-Dimethylphospholano)Benzene(Cyclooctadiene)Rhodium(I)Tetrafluoroborate is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation to ensure it meets the exacting standards required for asymmetric synthesis. Our quality protocols are designed to support cGMP and ISO-guided applications, guaranteeing batch-to-batch consistency and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline or amorphous solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	16.0 - 18.0 %
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.